تفاعل #640516

معادلة التفاعل

Phenacylbromid

4-(1H-benzimidazol-2-yl)-furazan-3-ylamine

potassium carbonate

→

title compound

4-(1-Phenacyl-1H-benzimidazol-2-yl)-furazan-3-ylamine

المذيبات

DMF

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   أخرىat room temperature
2. 2
   غسيلthe organic phase is washed repeatedly with brine
3. 3
   أخرىDrying of the solvent
4. 4
   ترشيحfiltering
5. 5
   أخرىevaporation of the solvent under reduced pressure

الإجراء التجريبي

Phenacylbromid (0.1 g, 0.49 mmol) is added to an efficiently stirred suspension of 4-(1H-benzimidazol-2-yl)-furazan-3-ylamine (0.1 g, 0.4 mmol) [A. V. Sergievskii, O. A. Krasnoshek, S. F. Mel'nikova, I. V. Tselinskii, Russian Journal of Organic Chemistry, 2002, 38, 915-917] and potassium carbonate (0.172 g, 1.24 mmol) in dry DMF (5 ml) at room temperature. After 4 hours the reaction mixture is diluted with ethyl acetate and the organic phase is washed repeatedly with brine. Drying of the solvent, filtering and evaporation of the solvent under reduced pressure gives the title compound in crude form. The title compound is obtained in pure form by chromatography over silicagel, m.p. 202-204° C.

المصدر