تفاعل #63975

معادلة التفاعل

formamide

N-formyl-1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine

→

hydrochloric acid

1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine

المذيبات

ظروف التفاعل

المعالجة

1. 1
   أخرىthe product isolated
2. 2
   درجة الحرارةby cooling the reaction mixture
3. 3
   أخرىcollecting the solid
4. 4
   أخرىproduced by filtration

الإجراء التجريبي

The preparation of N-formyl-1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine (m.p. 124°-125° C.) (Example 1(a) Formula I R1 =Me; R2 =H; R3 =H; R4 =CHO; R5 =4--Cl and R6 =3--Cl) described above was repeated and the product isolated by cooling the reaction mixture and collecting the solid produced by filtration. The formamide was then hydrolysed by concentrated hydrochloric acid in industrial methylated spirit to give the hydrochloride salt of 1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine.

المصدر