تفاعل #63949

معادلة التفاعل

6-nitro-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline

N,N-dimethylformamide dimethyl acetal

triethylamine

→

3-dimethylaminomethylene-6-nitro-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline

المردود 92.0%

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed
2. 2
   أخرىThe resulting precipitates
3. 3
   ترشيحwere collected by filtration
4. 4
   غسيلwashed with cold ethyl acetate
5. 5
   أخرىdried

الإجراء التجريبي

A mixture of 6-nitro-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline (2.976 g), N,N-dimethylformamide dimethyl acetal (8.568 g), and triethylamine (1.818 g) in benzene (24 ml) was refluxed with stirring for 2.5 hours and cooled to room temperature. The resulting precipitates were collected by filtration, washed with cold ethyl acetate, and dried to give 3-dimethylaminomethylene-6-nitro-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline (3.345 g).

المصدر