تفاعل #63797

معادلة التفاعل

2-amino-5-methylpyridine

sodium bicarbonate

ethyl 4-(2-bromoacetyl)benzoate

→

Ethyl 4-(6-methylimidazo[1,2-a]pyrid-2-yl)benzoate

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto reflux for 3 hours
2. 2
   workup.WAITleft
3. 3
   أخرىthe solid formed
4. 4
   ترشيحis recovered by filtration
5. 5
   غسيلwashed copiously with water
6. 6
   أخرىdried
7. 7
   أخرىIt is recrystallized in a dichloromethane/methanol mixture

الإجراء التجريبي

67 g (0.62 mole) of 2-amino-5-methylpyridine, 86 g (1.02 mole) of sodium bicarbonate and 143 g (0.527 mole) of ethyl 4-(2-bromoacetyl)benzoate are introduced into 1 l of ethanol. The mixture is brought to reflux for 3 hours and left standing for 19 hours, and the solid formed is recovered by filtration, washed copiously with water and dried. It is recrystallized in a dichloromethane/methanol mixture. M.p. 228°-230° C.

المصدر