تفاعل #63796

معادلة التفاعل

1-bromo-2-(4-trifluoromethylphenyl)-2-ethanone

2-amino-5-methylpyridine

sodium bicarbonate

→

6-Methyl-2-(4-trifluoromethylphenyl)imidazo[1,2-a]-pyridine

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthis suspension is heated
2. 2
   درجة الحرارةunder reflux until the evolution of gas
3. 3
   أخرىThe solvent is then evaporated off under reduced pressure
4. 4
   أخرىThe organic phase is decanted
5. 5
   تجفيفdried over magnesium sulphate
6. 6
   أخرىthe solvent is removed by evaporation under reduced pressure
7. 7
   أخرىThe residue is purified by column chromatography

الإجراء التجريبي

24 g (0.077 mole) of 1-bromo-2-(4-trifluoromethylphenyl)-2-ethanone, 8.4 g (0.077 mole) of 2-amino-5-methylpyridine and 13 g of sodium bicarbonate are mixed in 210 ml of 95% strength ethanol, and this suspension is heated under reflux until the evolution of gas has ceased. The solvent is then evaporated off under reduced pressure and the evaporation residue is taken up with water and dichloromethane. The organic phase is decanted and dried over magnesium sulphate, and the solvent is removed by evaporation under reduced pressure. The residue is purified by column chromatography.

المصدر