تفاعل #63762

معادلة التفاعل

2-[[(3,5-dimethyl-2-pyridyl)methyl]sulphinyl]-5 -(trifluoromethyl)benzimidazole

cysteamine

hydrochloric acid

→

2-[[(2-aminoethyl)dithio]methyl]-3,5-dimethyl-1 -[5-(trifluoromethyl)-2-benzimidazolyl]pyridinium chloride

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   أخرىat an internal temperature of 40°
2. 2
   أخرىsubseguently evaporated in vacuo
3. 3
   أخرىThe residue is crystallized from tert.butyl methyl ether/ether

الإجراء التجريبي

3.53 g of 2-[[(3,5-dimethyl-2-pyridyl)methyl]sulphinyl]-5 -(trifluoromethyl)benzimidazole are dissolved in 50 ml of tetrahydrofuran and treated with 0.77 g of cysteamine. 40 ml of 3N hydrochloric acid are added thereto at an internal temperature of 40°. The mixture is stirred at 40° overnight and subseguently evaporated in vacuo. The residue is crystallized from tert.butyl methyl ether/ether. There is obtained 2-[[(2-aminoethyl)dithio]methyl]-3,5-dimethyl-1 -[5-(trifluoromethyl)-2-benzimidazolyl]pyridinium chloride of melting point 115°-120°.

المصدر