تفاعل #63760

معادلة التفاعل

2-[[(3-methyl-2-pyridyl)methyl]sulphinyl]-5-(trifluoromethyl)benzimidazole

cysteamine

hydrochloric acid

→

2-[[(2-aminoethyl)dithio]methyl]-3 -methyl-1-[5-(trifluoromethyl)-2-benzimidazolyl1pyridinium chloride

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   أخرىis evaporated in vacuo
2. 2
   أخرىThe residue is crystallized from tert.butyl methyl ether/ether

الإجراء التجريبي

3.39 g of 2-[[(3-methyl-2-pyridyl)methyl]sulphinyl]-5-(trifluoromethyl)benzimidazole are dissolved in 50 ml of tetrahydrofuran and treated with 0.77 g of cysteamine. 40 ml of 3N hydrochloric acid are added at an internal temperature of 40°. After stirring at 40° for 10 minutes and at room temperature overnight the mixture is evaporated in vacuo. The residue is crystallized from tert.butyl methyl ether/ether. There is obtained 2-[[(2-aminoethyl)dithio]methyl]-3 -methyl-1-[5-(trifluoromethyl)-2-benzimidazolyl1pyridinium chloride of melting point 95°-100°.

المصدر