تفاعل #63642

معادلة التفاعل

trans-3,4,4a,5,6,11b-hexahydro-2H-[1]benzoxepino[5,4-b]-1,4-oxazine hydrochloride

triethylamine

chloroacetyl chloride

→

trans-N-chloroacetyl-3,4,4a,5,6,11b-hexahydro-2H-[1]-benzoxepino[5,4-b]-1,4-oxazine

المذيبات

methylene chloride

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with a dilute solution of hydrochloric acid
2. 2
   غسيلwash
3. 3
   غسيلa wash of dilute sodium hydroxide solution
4. 4
   غسيلfinally by a wash of a saturated solution of sodium chloride
5. 5
   تجفيفThe reaction mixture is dried over anhydrous magnesium sulfate
6. 6
   أخرىevaporated to dryness

الإجراء التجريبي

A solution of 1.21 g of trans-3,4,4a,5,6,11b-hexahydro-2H-[1]benzoxepino[5,4-b]-1,4-oxazine hydrochloride, prepared according to the procedure of Example 2, and 1.65 ml of triethylamine in 25 ml of methylene chloride is treated dropwise with a solution of 0.70 ml of chloroacetyl chloride dissolved in 10 ml of methylene chloride. The reaction mixture is stirred overnight at room temperature, washed with a dilute solution of hydrochloric acid, followed by a water wash, a wash of dilute sodium hydroxide solution and finally by a wash of a saturated solution of sodium chloride. The reaction mixture is dried over anhydrous magnesium sulfate and evaporated to dryness to obtain 1.44 g of trans-N-chloroacetyl-3,4,4a,5,6,11b-hexahydro-2H-[1]-benzoxepino[5,4-b]-1,4-oxazine.

المصدر