تفاعل #63592

معادلة التفاعل

N-(2-hydroxyethyl)-2-pyrazinecarboxamide

calcium oxide

hydrogen

→

N-(2-hydroxyethyl)-2-piperazinecarboxamide

المردود 100.0%

المذيبات

2-methoxyethanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe catalyst was filtered off
2. 2
   أخرىthe filtrate was evaporated

الإجراء التجريبي

A mixture of 53.7 parts of N-(2-hydroxyethyl)-2-pyrazinecarboxamide, 20 parts of calcium oxide and 500 parts of 2-methoxyethanol was hydrogenated at normal pressure and at room temperature with 5 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 55.4 parts (100%) of N-(2-hydroxyethyl)-2-piperazinecarboxamide as a residue (intermediate 23).

المصدر