تفاعل #63526

معادلة التفاعل

N-Ethyl-cyclohexylamine

chloroacetyl chloride

triethylamine

→

N-ethyl-N-cyclohexyl-chloroacetamide

المردود 72.1%

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooling
2. 2
   workup.ADDITIONThe reaction mixture is poured onto ice-water
3. 3
   استخلاصextracted with ether
4. 4
   غسيلThe ether layer is washed with an aqueous sodium hydrogen carbonate solution
5. 5
   تجفيفan aqueous saturated sodium chloride solution and dried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONAfter distilling off the solvent
7. 7
   workup.DISTILLATIONthe resulting residue is distilled under reduced pressure

الإجراء التجريبي

N-Ethyl-cyclohexylamine (2.6 g) is dissolved in dry benzene (20 ml). To the solution are added dropwise with stirring chloroacetyl chloride (2.6 g) and triethylamine (2.4 g) under ice-cooling. The mixture is stirred under ice-cooling for one hour and further at room temperature for one hour. The reaction mixture is poured onto ice-water and extracted with ether. The ether layer is washed with an aqueous sodium hydrogen carbonate solution and an aqueous saturated sodium chloride solution and dried over anhydrous magnesium sulfate. After distilling off the solvent, the resulting residue is distilled under reduced pressure to give N-ethyl-N-cyclohexyl-chloroacetamide (3 g), b.p. 118°-120° C./0.2 mmHg.

المصدر