تفاعل #635126

ord-0fc1abfe517d442f83bd3495612a207a

معادلة التفاعل

Cc1ccc(C=O)cc1O
3-hydroxy-4-methyl-benzaldehyde
CCI
ethyl iodide
O=C([O-])[O-].[K+].[K+]
K2CO3
→
CCOc1cc(C=O)ccc1C
title compound
CCOc1cc(C=O)ccc1C
3-Ethoxy-4-methyl-benzaldehyde

المتفاعلات

Cc1ccc(C=O)cc1O
3-hydroxy-4-methyl-benzaldehyde
CCI
ethyl iodide
O=C([O-])[O-].[K+].[K+]
K2CO3

الكواشف

لا شيء

المذيبات

CN(C)C=O
DMF

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The title compound was prepared by reaction of commercially available 3-hydroxy-4-methyl-benzaldehyde with ethyl iodide in DMF using K2CO3 as base in analogy to the procedure described in M. J. Ashton, D. C. Cook, G. Fenton, J.-A. Karlsson, M. N. Palfreyman, D. Raeburn, A. J. Ratcliffe, J. E. Souness, S. Thurairatnam and N. Vicker J. Med. Chem. 1994, 37, 1696-1703.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07939661B2uspto-grants-2011_05