تفاعل #63497

معادلة التفاعل

3-(13-nitro-6-methyl-8α-ergolinyl)-1,1-diethylurea

acetyl chloride

potassium hydroxide

→

3-(1-acetyl-6-methyl-13-nitro-8α-ergolinyl)-1,1-diethylurea

المذيبات

methylene chloride

sodium bicarbonate

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONare added
2. 2
   أخرىthe organic phase is separated
3. 3
   تجفيفdried with sodium sulfate
4. 4
   أخرىAfter evaporation and chromatography

الإجراء التجريبي

A solution is prepared from 410 mg of 3-(13-nitro-6-methyl-8α-ergolinyl)-1,1-diethylurea in 10 ml of methylene chloride, 40 mg of tetrabutylammonium hydrogen sulfate and 0.8 ml of acetyl chloride are added, and this mixture is poured on 1 g of pulverized potassium hydroxide. After 1.5 hours of agitation at room temperature, the mixture is diluted with sodium bicarbonate solution, the organic phase is separated and dried with sodium sulfate. After evaporation and chromatography as indicated in Example 9, 375 mg of 3-(1-acetyl-6-methyl-13-nitro-8α-ergolinyl)-1,1-diethylurea is obtained.

المصدر