تفاعل #63496

ord-0b54ebb2001341259c7e0f254d3e5497

معادلة التفاعل

CCN(CC)C(=O)N[C@H]1C[C@@H]2c3cc(N)cc4[nH]cc(c34)C[C@H]2N(C)C1
3-(13-amino-6-methyl-8α-ergolinyl)-1,1-diethylurea
CC(=O)O
acetic acid
B.CSC
borane-dimethyl sulfide
→
CCN(CC)C(=O)N[C@H]1C[C@@H]2c3cc(NC)cc4[nH]cc(c34)C[C@H]2N(C)C1
1,1-diethyl-3-(6-methyl-13-methylamino-8α-ergolinyl)urea

المتفاعلات

—
N-formyl
—
anhydride
CCN(CC)C(=O)N[C@H]1C[C@@H]2c3cc(N)cc4[nH]cc(c34)C[C@H]2N(C)C1
3-(13-amino-6-methyl-8α-ergolinyl)-1,1-diethylurea
CC(=O)O
acetic acid
B.CSC
borane-dimethyl sulfide
—
N-formyl

الكواشف

لا شيء

المذيبات

O=CO
formic acid

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

At -20° C., 355 mg of 3-(13-amino-6-methyl-8α-ergolinyl)-1,1-diethylurea is reacted to the N-formyl compound with the mixed anhydride of acetic acid and formic acid and the N-formyl compound is reduced with borane-dimethyl sulfide (S. Krishnamurty, Tetrahedron Letters 1982: 3315). After chromatography, 260 mg of 1,1-diethyl-3-(6-methyl-13-methylamino-8α-ergolinyl)urea is obtained.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US04766128uspto-grants-1988_08