تفاعل #634653

معادلة التفاعل

1-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethyl-propan-1-one

3-ethylphenylboronic acid

K2CO3

Dioxane

→

1-[2-(3-ethyl-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one

المردود 50.0%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   أخرىthe tube was microwaved at 150° C. for 45 min
2. 2
   ترشيحThe reaction mixture was filtered through a plug of celite
3. 3
   أخرىThe filtrate was collected
4. 4
   أخرىpartitioned between EtOAc/water
5. 5
   أخرىThe organic layers were collected
6. 6
   تجفيفdried over MgSO4
7. 7
   ترشيحfiltered
8. 8
   تركيزconcentrated
9. 9
   أخرىgiving a dark brown solid
10. 10
    أخرىThe crude product was purified by silica gel chromatography

الإجراء التجريبي

A microwave tube was charged with 1-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethyl-propan-1-one (152 mg, 0.54 mmol), 3-ethylphenylboronic acid (89 mg, 0.59 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloro-palladium(II) (35 mg, 0.042 mmol), and K2CO3 (186 mg, 1.34 mmol). Dioxane (4 ml) and water (1 ml) were added, and the tube was microwaved at 150° C. for 45 min. The reaction mixture was filtered through a plug of celite. The filtrate was collected and partitioned between EtOAc/water. The organic layers were collected, dried over MgSO4, filtered, and concentrated giving a dark brown solid. The crude product was purified by silica gel chromatography using 20-50% EtOAc in hexanes as eluant provided 82 mg (50%) of 1-[2-(3-ethyl-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one as a yellow solid. MP 199-200.1° C., M+H=308.

المصدر