تفاعل #63461

معادلة التفاعل

6-(3,4-Dihydro-1,4(2H)-benzoxazin-6-yl)-2,3,4,5-tetrahydropyridazin-3-one

triethylamine

3,4-dimethoxybenzoylchloride

→

6-(3,4-Dihydro-4-(3,4-dimethoxyphenylcarbonyl)-1,4(2H)-benzoxazin-6-yl)-2,3,4,5-tetrahydropyridazin-3-one

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture heated
2. 2
   درجة الحرارةat reflux for four hours
3. 3
   غسيلThe solution was washed with sodium bicarbonate solution
4. 4
   أخرىevaporated to dryness
5. 5
   أخرىThe residue was chromatographed on silica gel eluting with 1:1 ethyl acetate
6. 6
   أخرىThe title compound was collected as white needles, mp 207°-208° C.

الإجراء التجريبي

6-(3,4-Dihydro-1,4(2H)-benzoxazin-6-yl)-2,3,4,5-tetrahydropyridazin-3-one was dissolved in methylene chloride and 1.1 equivalent of triethylamine. 1.1 equivalent of 3,4-dimethoxybenzoylchloride was added and the mixture heated at reflux for four hours. The solution was washed with sodium bicarbonate solution and then evaporated to dryness. The residue was chromatographed on silica gel eluting with 1:1 ethyl acetate:ethyl ether. The title compound was collected as white needles, mp 207°-208° C.

المصدر