تفاعل #63398

معادلة التفاعل

9-bromo-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepin-6-one

4-methylpiperidine

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product

المردود 83.0%

9-Bromo-6-(4-methyl-1-piperidinyl)-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepine

المردود 83.0%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated under nitrogen
2. 2
   أخرىresulted
3. 3
   درجة الحرارةThe mixture was refluxed for 3 hours
4. 4
   ترشيحfiltered
5. 5
   workup.STIRRINGThe filtrate was stirred with 500 ml of 2N sodium hydroxide solution for 15 minutes
6. 6
   أخرىthe layers were separated
7. 7
   استخلاصThe aqueous phase was extracted with 250 ml of toluene
8. 8
   غسيلwashed once with 2N sodium hydroxide solution, twice with water
9. 9
   تجفيفdried over anhydrous sodium sulfate
10. 10
    ترشيحfiltered
11. 11
    تركيزconcentrated in vacuo to an oil which
12. 12
    أخرىThe solid was triturated twice with hexane

الإجراء التجريبي

A mixture of 4.73 g (0.015 mole) of 9-bromo-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepin-6-one and 1000 ml of toluene was heated under nitrogen, with stirring, until a solution resulted. Then there was added 14.9 g (0.150 mole) of 4-methylpiperidine, followed by 8.54 g (0.045 mole) of titanium tetrachloride. The mixture was refluxed for 3 hours, cooled to room temperature and filtered. The filtrate was stirred with 500 ml of 2N sodium hydroxide solution for 15 minutes and the layers were separated. The aqueous phase was extracted with 250 ml of toluene. The toluene layers were combined, washed once with 2N sodium hydroxide solution, twice with water, dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo to an oil which solidified. The solid was triturated twice with hexane to afford 4.9 g (83%) of product. Recrystallization from ethyl acetate provided the analytical sample, mp 177°-179° C.

المصدر