تفاعل #63366

معادلة التفاعل

n-butyl bromide

sodium hydride

1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione

→

3-n-butyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione

المذيبات

N,N-dimethylformamide

N,N-dimethylformamide

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONare then added dropwise
2. 2
   أخرىThe residue is partitioned between ethyl acetate and water
3. 3
   تجفيفthe organic phase is dried over magnesium sulphate
4. 4
   تركيزafter concentration
5. 5
   أخرىby evaporation and subsequent recrystallisation from ethyl acetate/petroleum ether
6. 6
   أخرىthe product is obtained

الإجراء التجريبي

0.36 g of sodium hydride is added to a solution of 2.46 g of 1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione in 25 ml of N,N-dimethylformamide and the whole is stirred at room temperature for 30 minutes. 1.6 ml of n-butyl bromide dissolved in 10 ml of N,N-dimethylformamide are then added dropwise thereto. When the reaction is complete, the reaction mixture is freed of N,N-dimethylformamide. The residue is partitioned between ethyl acetate and water, and the organic phase is dried over magnesium sulphate and, after concentration by evaporation and subsequent recrystallisation from ethyl acetate/petroleum ether, the product is obtained having a melting point of 120°-123°.

المصدر