تفاعل #633643

معادلة التفاعل

Benzyl (1R*,3S*,4R*)-3,4-epoxycyclohexane-1-carboxylate

ammonium chloride

sodium azide

→

title compound

المردود 99.7%

Benzyl (1R*,3S*,4S*)-4-azido-3-hydroxycyclohexane-1-carboxylate

المردود 99.7%

المذيبات

N,N-dimethyl-formamide

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure, and water
2. 2
   workup.ADDITIONwas added
3. 3
   استخلاصextraction with ethyl acetate
4. 4
   غسيلThe resultant organic layer was washed with saturated saline
5. 5
   تجفيفdried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

الإجراء التجريبي

Benzyl (1R*,3S*,4R*)-3,4-epoxycyclohexane-1-carboxylate (52.3 g) was dissolved in N,N-dimethyl-formamide (1000 ml), ammonium chloride (21.9 g) and sodium azide (18.1 g) were added, and the mixture was heated to 70° C. and stirred for 24 hours. The solvent was distilled off under reduced pressure, and water was added to conduct extraction with ethyl acetate. The resultant organic layer was washed with saturated saline and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (61.8 g) as a colorless oil.

المصدر