تفاعل #63299

معادلة التفاعل

2,2,3,3,4,4,4-heptafluoro-N-[4-(cyano)phenyl]butanamide

sodium azide

ammonium chloride

dimethylformamide

→

title compound

2,2,3,3,4,4,4-Heptafluoro-N-[4-(1H-tetrazol-5-yl)phenyl]butanamide

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated in a 130°-135° C. oil bath overnight
2. 2
   ترشيحthe resulting solid was filtered off
3. 3
   أخرىrecrystallized from ethanol
4. 4
   أخرىThe product was dried at 100° C. overnight
5. 5
   أخرىan abderhalden (drying pistol)

الإجراء التجريبي

A mixture of 2,2,3,3,4,4,4-heptafluoro-N-[4-(cyano)phenyl]butanamide (1.5 g,) sodium azide (1.55 g), ammonium chloride (1.28 g) and dimethylformamide (20 mL) was heated in a 130°-135° C. oil bath overnight. The reaction mixture was then poured onto 200 mL of water and the resulting solid was filtered off and recrystallized from ethanol. The product was dried at 100° C. overnight using an abderhalden (drying pistol) to give the title compound, m.p. 266°-268° C.

المصدر