تفاعل #63254

معادلة التفاعل

tetramethylguanidinium azide

2-propylresorcinol

5-bromovaleronitrile

→

tetrazole

5-[4-(2-propyl-3-hydroxyphenoxy)butyl]-tetrazole

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىto provide 3.4 g
2. 2
   أخرىThe solvent was removed under reduced pressure
3. 3
   workup.DISSOLUTIONthe residue was dissolved in ethyl acetate
4. 4
   غسيلThe organic solution was washed with water
5. 5
   أخرىThe organic layer was dried
6. 6
   أخرىevaporated

الإجراء التجريبي

Six grams of 2-propylresorcinol and 6.4 g. of 5-bromovaleronitrile were reacted following cedure of Example 2A to provide 3.4 g. of the desired nitrile intermediate. This intermediate was heated to 125° C. overnight with 40 mmoles of tetramethylguanidinium azide in 10 ml. of dimethylformamide. The solvent was removed under reduced pressure and the residue was dissolved in ethyl acetate. The organic solution was washed with water adjusted to pH 6. The organic layer was dried and evaporated to yield the desired subtitle tetrazole intermediate which crystallized after evaporation of the solvent. NMR.

المصدر