تفاعل #63186

معادلة التفاعل

2-(4-oxo-3-thiazolidinyl)propionic acid

2.6-dimethylaniline

dicyclohexylcarbodiimide

→

N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide

المردود 45.7%

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed for 48 hours
2. 2
   أخرىThe resultant precipitate was removed by filtration
3. 3
   أخرىthe filtrate was evaporated in vacuo
4. 4
   أخرىThe residue was triturated with diethyl ether
5. 5
   أخرىrecrystallized from ethanol

الإجراء التجريبي

A mixture of 2-(4-oxo-3-thiazolidinyl)propionic acid (2.00 g), 2.6-dimethylaniline (1.38 g), and dicyclohexylcarbodiimide (2.35 g) in chloroform (15 ml) was refluxed for 48 hours. The resultant precipitate was removed by filtration and the filtrate was evaporated in vacuo. The residue was triturated with diethyl ether and recrystallized from ethanol to give N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide (1.45 g) as colorless prisms.

المصدر