تفاعل #63158

ord-3119056b194f4375a604830debadd30b

معادلة التفاعل

CC(C)(C)NS(=O)(=O)c1ccccc1C=C1CCOC1=O
product
CC(C)(C)NS(=O)(=O)c1ccccc1C=C1CCOC1=O
N-(1,1-Dimethylethyl)-2-[(2-oxo-tetrahydro-3-furanylidene)methyl]benzenesulfonamide
→
NS(=O)(=O)c1ccccc1C=C1CCOC1=O
title compound
المردود 88.8%
NS(=O)(=O)c1ccccc1C=C1CCOC1=O
2-[(2-oxotetrahydro-3-furanylidene)methyl] benzenesulfonamide
المردود 88.8%

المتفاعلات

CC(C)(C)NS(=O)(=O)c1ccccc1C=C1CCOC1=O
product
CC(C)(C)NS(=O)(=O)c1ccccc1C=C1CCOC1=O
N-(1,1-Dimethylethyl)-2-[(2-oxo-tetrahydro-3-furanylidene)methyl]benzenesulfonamide

الكواشف

لا شيء

المذيبات

O=C(O)C(F)(F)F
trifluoroacetic acid

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىwas then evaporated

الإجراء التجريبي

A solution of 5.0 g (0.016 mol) of the product of Example 2 in 70 mL trifluoroacetic acid was stirred at room temperature overnight and was then evaporated to yield 3.6 g (88%) of the title compound: m.p. 178°-180°; IR (nujol) 3330, 3230, 3220, 1720, 1640, 1340, 1160, cm-1 ; NMR (DMSO-d6, 200 MHz) δ 3.12 (2H, m) 4.36 (2H, t, J=7 Hz), 7.5-7.7 (3H, m), 7.93 (1H, m), 8.07 (1H, m).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US04764207uspto-grants-1988_08