تفاعل #63131

معادلة التفاعل

hydrochloric acid

3-tetradecylphenol

acetate

aluminum chloride

→

desired compound

1-(2-Hydroxy-4-tetradecylphenyl)ethanone

المذيبات

ether

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto cool
2. 2
   استخلاصextracted several times with ether
3. 3
   غسيلwashed with water, brine
4. 4
   أخرىdried
5. 5
   أخرىThe crude material was chromatographed on silica gel
6. 6
   غسيلeluting with hexane:ethyl acetate (50:1)

الإجراء التجريبي

A 20 g portion of 3-tetradecylphenol, acetate was heated at 110° C. and 8.4 g of aluminum chloride was added in portions over a 3 hour period. The mixture was allowed to cool, then diluted with ether, poured onto ice containing 10 ml of concentrated hydrochloric acid and extracted several times with ether. The ether extracts were combined, washed with water, brine and dried. The crude material was chromatographed on silica gel, eluting with hexane:ethyl acetate (50:1), giving 15.8 g of the desired compound, mp 45°-46° C.

المصدر