تفاعل #63092

معادلة التفاعل

2-[2-(2,2,2-trifluoroethyl)guanidino]-4-[4-(3-[2-aminophenyl]thioureido)butyl]thiazole

triethylamine

→

2-[4-(2-[2-(2,2,2-trifluoroethyl)guanidino]thiazol-4-yl)butylamino]benzimidazole

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىHydrogen sulphide gas was then bubbled through the reaction mixture until no more solid
2. 2
   أخرىprecipitated
3. 3
   ترشيحThe reaction mixture was filtered through a pad of diatomaceous earth
4. 4
   أخرىthe filtrate evaporated to dryness in vacuo
5. 5
   أخرىThe residue was purified by low pressure liquid chromatography

الإجراء التجريبي

A mixture of 2-[2-(2,2,2-trifluoroethyl)guanidino]-4-[4-(3-[2-aminophenyl]thioureido)butyl]thiazole (0.45 g.), silver nitrate (0.34 g.) and triethylamine (0.28 ml.) in dimethylformamide (3 ml.) was stirred vigorously at ambient temperature overnight. Hydrogen sulphide gas was then bubbled through the reaction mixture until no more solid precipitated. The reaction mixture was filtered through a pad of diatomaceous earth and the filtrate evaporated to dryness in vacuo. The residue was purified by low pressure liquid chromatography using chloroform/methanol/ammonia, 9:1:0.1 v/v/v as eluant to give 2-[4-(2-[2-(2,2,2-trifluoroethyl)guanidino]thiazol-4-yl)butylamino]benzimidazole which was converted to the hydrogen maleate salt (0.25 g.), m.p. 183°-186°.

المصدر