تفاعل #62991

معادلة التفاعل

sodium hydrogencarbonate

diethylamine

sodium carbonate

2-n-butyl-3-bromo-5,6-methylenedioxyindene

→

2-n-butyl-3-diethylamino-5,6-methylenedioxyindene

المردود 65.0%

المذيبات

dimethylsulfoxide

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added at room temperature
2. 2
   أخرىAfter completion of the reaction
3. 3
   استخلاصextracted with ether
4. 4
   غسيلThe ethereal layer was washed with water
5. 5
   تجفيفdried over anhydrous magnesium sulfate
6. 6
   تركيزconcentrated under reduced pressure
7. 7
   أخرىThe residue was purified by column chromatography on silica gel (eluent
8. 8
   workup.ADDITIONa 10:1 mixture of n-hexane and ether)
9. 9
   أخرىto give 380 mg of an oily substance (yield: 65%)

الإجراء التجريبي

To a solution containing 300 mg of diethylamine and 430 mg of sodium carbonate in 6 ml of dimethylsulfoxide, 600 mg of 2-n-butyl-3-bromo-5,6-methylenedioxyindene was added at room temperature. The reaction mixture was stirred for 5 hours. After completion of the reaction, the reaction mixture was added with a saturated aqueous solution of sodium hydrogencarbonate and then extracted with ether. The ethereal layer was washed with water, dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: a 10:1 mixture of n-hexane and ether) to give 380 mg of an oily substance (yield: 65%).

المصدر