تفاعل #6286

معادلة التفاعل

4-mercaptopyridine

1-bromo-4-chlorobutane

triethylamine

→

desired compound

المردود 89.7%

4-(4-chlorobutylthio)pyridine

المردود 89.7%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   workup.DISTILLATIONThe solvent was distilled off
3. 3
   workup.ADDITIONchloroform was added to the residue
4. 4
   غسيلThe mixture was washed with water
5. 5
   تجفيفdried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONThe solvent was distilled off
7. 7
   أخرىthe residue was purified by column chromatography (eluent: ethyl acetate/n-hexane =1:1)

الإجراء التجريبي

To a suspension of 33.35 g (0.30 mol) of 4-mercaptopyridine and 51.44 g (0.30 mol) of 1-bromo-4-chlorobutane in 500 ml of ethanol, 41.9 ml (0.30 mol) of triethylamine was added, and the mixture was stirred at room temperature for 5 hours. The solvent was distilled off and chloroform was added to the residue. The mixture was washed with water and dried over anhydrous magnesium sulfate. The solvent was distilled off and the residue was purified by column chromatography (eluent: ethyl acetate/n-hexane =1:1) to give 54.27 g of the desired compound (89.7% yield, colorless oil).

المصدر