تفاعل #62856

معادلة التفاعل

2-chloro-5-fluoro-4-methyl-3-nitro-benzoic acid

Na2S2O4

HCl

→

3-Amino-2-chloro-5-fluoro-4-methyl-benzoic acid

المذيبات

water

glycol monomethyl ether

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooled
2. 2
   أخرىThe solid which has precipitated
3. 3
   أخرىis isolated
4. 4
   أخرىdried

الإجراء التجريبي

18.5 g of 2-chloro-5-fluoro-4-methyl-3-nitro-benzoic acid and 51.5 g of Na2S2O4 are boiled in a mixture of 160 ml of glycol monomethyl ether and 160 g of water for 3 hours. 230 ml of 1/2-concentrated HCl are added to the still warm solution. The mixture is boiled up once more, cooled and poured into 560 ml of water. The solid which has precipitated is isolated and dried. Yield: 12.4 g, melting point: 182°-84°.

المصدر