تفاعل #6276

معادلة التفاعل

2-[4-(2-aminobenzoylamino)butylthio]pyridine

1,1'-carbonyldiimidazole

→

desired product

المردود 68.8%

3-[4-(2-pyridylthio)butyl]-quinazoline-2,4(1H,3H)-dione

المردود 68.8%

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONThe solvent was distilled off
2. 2
   workup.DISSOLUTIONthe residue was dissolved in chloroform
3. 3
   غسيلThe solution was washed with water
4. 4
   أخرىdried
5. 5
   workup.DISTILLATIONThe solvent was distilled off
6. 6
   أخرىthe residue was recrystallized from chloroform/ether

الإجراء التجريبي

Under nitrogen atmosphere, to a solution of 452 mg (1.5 mmol) of 2-[4-(2-aminobenzoylamino)butylthio]pyridine in 20 ml of tetrahydrofuran, 486 mg (3.0 mmol) of 1,1'-carbonyldiimidazole was added, and the mixture was stirred at room temperature for 16 hours. The solvent was distilled off and the residue was dissolved in chloroform. The solution was washed with water and dried. The solvent was distilled off and the residue was recrystallized from chloroform/ether to give 337 mg of the desired product (68.8% yield, white crystals).

المصدر