تفاعل #62735

معادلة التفاعل

7-chloro-8-aminoquinoline

2,4-diamino-5-hydroxymethylpyrimidine

hydrochloric acid

→

title compound

المردود 79.0%

2,4-Diamino-5-(8-amino-7-chloro-5-quinolylmethyl)pyrimidine dihydrochloride

المردود 79.0%

المذيبات

acetic acid

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe resulting precipitate was filtered from the cooled reaction mixture
2. 2
   غسيلwashed with cold acetic acid and ether

الإجراء التجريبي

A solution of 7-chloro-8-aminoquinoline (C. C. Price and D. B. Guthrie, J. Amer. Chem. Soc. 1946, 68, 1592) (3.17 g, 17.7 mmol), 2,4-diamino-5-hydroxymethylpyrimidine (2.50 g, 17.7 mmol), and concentrated hydrochloric acid (2.50 mL) in glacial acetic acid (32 mL) was refluxed for 5 hr. The resulting precipitate was filtered from the cooled reaction mixture and washed with cold acetic acid and ether to give the title compound as tan solid (5.19 g, 79%); mp >290° dec. Anal. Calcd for C14H13ClN6.2HCl: C, 45.00; H, 4.05; N, 22.49; Cl, 28.46. Found: C, 44.89; H, 4.08; N, 22.44; Cl, 28.38.

المصدر