تفاعل #6272

معادلة التفاعل

4-[3-(2-pyrazinecarbonylamino)propylthio]pyridine

hydrochloric acid methanol

→

desired compound

المردود 85.6%

4-[3-(2-pyrazinecarbonylamino)propylthio]pyridine dihydrochloride

المردود 85.6%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONThe solvent was distilled off
2. 2
   أخرىthe residue was purified by recrystallization (solvent: ethanol-ether)

الإجراء التجريبي

To a solution of 704.5 mg (2.57 mmol) of 4-[3-(2-pyrazinecarbonylamino)propylthio]pyridine in 30 ml of methanol, 70 ml of 10% hydrochloric acid-methanol was added, and the mixture was stirred at room temperature for 2 hours. The solvent was distilled off and the residue was purified by recrystallization (solvent: ethanol-ether) to give 842.4 mg of the desired compound (85.6% yield, pale yellow crystals).

المصدر