تفاعل #62651

معادلة التفاعل

6-methyl-1,2,3,4-tetrahydroquinoline

1f

9-fluoro-6-(4-methyl-1piperazinyl)-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepine

2-fluoronitrobenzene

→

6-methyl-1-(2-nitrophenyl)-1,2,3,4-tetrahydroquinoline

1-(2-aminophenyl)-6-methyl-1,2,3,4-tetra-hydroquinoline

5-methyl-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino[1,8-ab][1,5]-benzodiazepine

ظروف التفاعل

الإجراء التجريبي

Starting with 6-methyl-1,2,3,4-tetrahydroquinoline and 2-fluoronitrobenzene and following steps 1a to 1f of Example 2, one may obtain, in sequence, 6-methyl-1-(2-nitrophenyl)-1,2,3,4-tetrahydroquinoline, 1-(2-aminophenyl)-6-methyl-1,2,3,4-tetra-hydroquinoline, N-[2-(6-methyl-1-phenyl)-1,2,3,4-tetrah quinolin-1-yl]-4-methyl-1-piperazine carboxamide, and 5-methyl-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino[1,8-ab][1,5]-benzodiazepine.

المصدر