تفاعل #6265

معادلة التفاعل

2,4-thiazolidinedione

4-chlorobenzaldehyde

piperidine

→

desired compound

المردود 43.4%

5-(4-chlorobenzylidene)-2,4-thiazolidinedione

المردود 43.4%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture was heated
2. 2
   درجة الحرارةunder reflux for 5 hours
3. 3
   درجة الحرارةAfter cooling
4. 4
   ترشيحthe precipitated crystals were filtered
5. 5
   غسيلwashed with cooled ethanol

الإجراء التجريبي

To a solution of 20 g (171 mmol) of 2,4-thiazolidinedione and 17.4 ml (171 mmol) of 4-chlorobenzaldehyde in 350 ml of ethanol, 1.68 ml (17.1 mmol) of piperidine was added, and the mixture was heated under reflux for 5 hours. After cooling, the precipitated crystals were filtered and washed with cooled ethanol to give 17.75 g of the desired compound (43.4% yield, pale yellow crystals).

المصدر