تفاعل #62582

معادلة التفاعل

dl-2-amino-1-propanol

hexadecanoyl chloride

→

title compound

المردود 51.0%

2-(N-Hexadecanoyl)amino-1-propanol

المردود 51.0%

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   تركيزThe solution was concentrated
2. 2
   أخرىdecanted
3. 3
   تركيزThe solution was concentrated
4. 4
   أخرىthe residue was chromatographed on silica gel using 50% ethylacetate in hexane

الإجراء التجريبي

A solution of 4.00 g (53.2 mmol) of commercially obtained dl-2-amino-1-propanol b and 8.0 g (8.8 ml, 29.3 mmol) of hexadecanoyl chloride in 100 ml of CH2Cl2 was stirred at room temperature for hours. The solution was concentrated and the residue was boiled with 200 ml acetone and decanted. The solution was concentrated and the residue was chromatographed on silica gel using 50% ethylacetate in hexane to afford 4.15 g (51%) of the title compound as white needles, m.p. 75-76° C. Using the same procedure as in Example 19, the following compounds were prepared:

المصدر