تفاعل #6257

معادلة التفاعل

4-(3-phthalimidopropyloxy)pyridine

hydrogen chloride methanol

→

desired compound

المردود 64.8%

4-(3-phthalimidopropyloxy)pyridine hydrochloride

المردود 64.8%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONThe solvent was distilled off
2. 2
   workup.ADDITIONacetone was added to the residue
3. 3
   ترشيحThe resulting crystals were collected by filtration
4. 4
   غسيلwashed with acetone

الإجراء التجريبي

To a solution of 1.41 g (5.0 mmol) of 4-(3-phthalimidopropyloxy)pyridine in 20 ml of methanol, 10 ml of hydrogen chloride-methanol was added. The solvent was distilled off and acetone was added to the residue. The resulting crystals were collected by filtration and washed with acetone to give 1.03 g of the desired compound (64.8% yield, colorless crystals), mp. 167°-169° C.

المصدر