تفاعل #625527

معادلة التفاعل

2-bromo-5-fluoro-4-(2-methyl-aziridin-2-yl)-pyridine

Ph3PO

2-nitrobenzene-1-sulfonyl chloride

N-methylmorpholine

→

title compound

2-Bromo-5-fluoro-4-[2-methyl-1-(2-nitro-benzenesulfonyl)-aziridin-2-yl]-pyridine

المذيبات

THF

H2O

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONAlox neutral (2-3 spatula) was added
2. 2
   ترشيحthe reaction mixture was filtered through celite
3. 3
   غسيلwashed with DCM
4. 4
   workup.ADDITIONthe filtrates were diluted with DCM and 1M aq. NaHCO3 soln
5. 5
   أخرىThe phases were separated
6. 6
   تجفيفphases were dried over Na2SO4
7. 7
   تركيزconcentrated
8. 8
   أخرىFlash chromatography on silica gel (heptane:EtOAc 4:1 to 3:1) followed by recrystallization from EtOAc/hexane

الإجراء التجريبي

To a solution of crude 2-bromo-5-fluoro-4-(2-methyl-aziridin-2-yl)-pyridine (3.17 g as a 45% mixture with Ph3PO, 6.17 mmol) and 2-nitrobenzene-1-sulfonyl chloride (1.368 g, 6.17 mmol) in THF (23.15 mL) and H2O (7.72 mL) was added N-methylmorpholine and the reaction mixture was stirred at rt for 1.5 h. Alox neutral (2-3 spatula) was added and the reaction mixture was filtered through celite, washed with DCM and the filtrates were diluted with DCM and 1M aq. NaHCO3 soln. The phases were separated and the aq. phase was reextracted twice with DCM. The combined org. phases were dried over Na2SO4 and concentrated. Flash chromatography on silica gel (heptane:EtOAc 4:1 to 3:1) followed by recrystallization from EtOAc/hexane yielded the title compound as a colourless solid. HPLC RtH4=1.11 min; ESIMS: 416, 418 [(M+H)+]; 1H NMR (400 MHz, CDCl3): δ 8.31-8.30 (m, 1H), 8.23 (d, 1H), 7.86-7.77 (m, 3H), 7.68 (d, 1H), 3.28 (s, 1H), 2.78 (s, 1H), 2.09 (s, 3H).

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