تفاعل #62548

معادلة التفاعل

Methyl chloroacetate

N-methylpiperazine

→

2-(4-methyl-1-piperazinyl)acetic acid, methyl ester

المردود 95.0%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction mixture was filtered
2. 2
   أخرىthe solvent was removed under vacuum
3. 3
   workup.DISSOLUTIONThe resulting oil was dissolved in methylene chloride-methanol (9:1)
4. 4
   أخرىpurified by flash chromatography (silica)

الإجراء التجريبي

Methyl chloroacetate (8.8 ml., 0.10 mole) was added to a solution of N-methylpiperazine (24.4. ml., 0.22 mole) in ethyl acetate (140 ml.) and the mixture was stirred for 17 hours. The reaction mixture was filtered and the solvent was removed under vacuum. The resulting oil was dissolved in methylene chloride-methanol (9:1) and purified by flash chromatography (silica) to give 2-(4-methyl-1-piperazinyl)acetic acid, methyl ester as an oil (16.3 g, 95%).

المصدر