تفاعل #625192

معادلة التفاعل

sodium hydroxide

1-(4-nitrophenyl)piperidine-4-carboxylic acid ethyl ester

water

hydrochloric acid

→

1-(4-nitrophenyl)piperidine-4-carboxylic acid

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was refluxed
2. 2
   درجة الحرارةunder heat for 1 hour
3. 3
   ترشيحthe precipitate was collected by filtration

الإجراء التجريبي

The 1-(4-nitrophenyl)piperidine-4-carboxylic acid ethyl ester (2.78 g, 10 mmol) obtained in Example 2(1) was dissolved in ethanol (10 ml), and a 4 N sodium hydroxide aqueous solution (5 ml, 20 mmol) was added thereto. The mixture was refluxed under heat for 1 hour. After cooling to room temperature, water (30 ml) and 2 N hydrochloric acid (10 ml) were added to the mixture, and the precipitate was collected by filtration, thereby obtaining 1-(4-nitrophenyl)piperidine-4-carboxylic acid (2.47 g, 97%) as a yellow solid.

المصدر