تفاعل #62440

معادلة التفاعل

6-chloro-4-[1-(1-tert.-butyloxycarbonyl-5-chloro-1H-benzimidazol-2-yl)-3-hydroxycarbonyl-propyl-amino]-7-(pyrrolidin-1-yl-carbonyl)-quinazoline

methylamino-acetic acid dimethylamide

TBTU

trifluoroacetic acid

→

6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-3-(N-dimethylaminocarbonylmethyl-N-methyl-amino-carbonyl)-propyl-amino]-7-(pyrrolidin-1-yl-carbonyl)-quinazoline

المذيبات

acetonitrile tetrahydrofuran

ظروف التفاعل

الإجراء التجريبي

Prepared analogously to Example 61 from 6-chloro-4-[1-(1-tert.-butyloxycarbonyl-5-chloro-1H-benzimidazol-2-yl)-3-hydroxycarbonyl-propyl-amino]-7-(pyrrolidin-1-yl-carbonyl)-quinazoline and methylamino-acetic acid dimethylamide with TBTU in acetonitrile/tetrahydrofuran and subsequent reaction with trifluoroacetic acid.

المصدر