تفاعل #62353

معادلة التفاعل

1-acetyl-1H-thieno[2,3-c]pyrazole-5-carbonitrile

hydrochloric acid

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title compound

المردود 100.2%

1H-Thieno[2,3-c]pyrazole-5-carbonitrile

المردود 100.2%

المذيبات

ethanol

sodium hydroxide

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added at room temperature
2. 2
   استخلاصextracted with ethyl acetate
3. 3
   غسيلthe organic layer was washed with saturated brine
4. 4
   تجفيفdried over anhydrous magnesium sulfate
5. 5
   أخرىthe solvent was evaporated

الإجراء التجريبي

To a suspension of 215 mg of 1-acetyl-1H-thieno[2,3-c]pyrazole-5-carbonitrile in 8 mL of ethanol, 1 mL of 5N sodium hydroxide aqueous solution was added at room temperature, and stirred at this temperature for 10 minutes. Then the solution was neutralized with 5N hydrochloric acid, extracted with ethyl acetate, and the organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated, to afford 168 mg of the title compound as colorless crystals.

المصدر