تفاعل #62349

معادلة التفاعل

sodium thiosulfate

(2-chlorothiophen-3-yl)methanol

N-bromosuccinimide

→

title compound

المردود 80.6%

(5-Bromo-2-chlorothiophen-3-yl)methanol

المردود 80.6%

المذيبات

ethyl acetate

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   غسيلThe organic layer was washed successively with saturated aqueous ammonium chloride and saturated brine
2. 2
   تجفيفdried over anhydrous magnesium sulfate
3. 3
   أخرىthe solvent was evaporated

الإجراء التجريبي

To a solution of 3.0 g of (2-chlorothiophen-3-yl)methanol in 60 mL of dimethylformamide was added 3.59 g of N-bromosuccinimide at room temperature, and stirred at this temperature for 2 hours. Adding 10 mL of 10% sodium thiosulfate, and the resultant solution was diluted with ethyl acetate. The organic layer was washed successively with saturated aqueous ammonium chloride and saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated, to afford 3.7 g of the title compound as a colorless oil.

المصدر