تفاعل #62300

معادلة التفاعل

5-bromo-2,3-difluoro-4-trimethylsilanyl benzaldehyde

cesium fluoride

→

title compound

المردود 75.6%

5-Bromo-2,3-difluoro Benzaldehyde

المردود 75.6%

المذيبات

N,N-dimethylformamide

water

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   غسيلthe organic layer was washed successively with saturated aqueous ammonium chloride and saturated brine
2. 2
   تجفيفdried over anhydrous magnesium sulfate
3. 3
   أخرىthe solvent was evaporated

الإجراء التجريبي

To a solution of 18.0 g of 5-bromo-2,3-difluoro-4-trimethylsilanyl benzaldehyde in 20 mL of N,N-dimethylformamide and 2 mL of water was added 1.63 g of cesium fluoride at room temperature, and stirred at this temperature for 1 hour. After diluting with ethyl acetate, the organic layer was washed successively with saturated aqueous ammonium chloride and saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated, to afford 10.26 g of the title compound as a colorless oil.

المصدر