تفاعل #6216

معادلة التفاعل

4-(3-aminopropylthio)pyridine dihydrochloride

triethylamine

2-furoyl chloride

→

desired compound

المردود 87.3%

4-[3-(2-furoylamino)propylthio]pyridine

المردود 87.3%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooling
2. 2
   workup.STIRRINGThe mixture was stirred at room temperature for 30 minutes
3. 3
   غسيلThe reaction mixture was washed with a saturated aqueous solution of sodium bicarbonate and water
4. 4
   أخرىdried
5. 5
   workup.DISTILLATIONthe solvent was distilled off
6. 6
   أخرىThe residue was purified by column chromatography (eluent: ethyl acetate)
7. 7
   أخرىto obtain powder
8. 8
   غسيلThe powder was washed with ether
9. 9
   أخرىdried

الإجراء التجريبي

To a solution of 1.00 g (4.15 mmol) of 4-(3-aminopropylthio)pyridine dihydrochloride and 2.78 ml (19.9 mmol) of triethylamine in 40 ml of methylene chloride, 0.49 ml (4.98 mmol) of 2-furoyl chloride was added under ice-cooling with stirring. The mixture was stirred at room temperature for 30 minutes. The reaction mixture was washed with a saturated aqueous solution of sodium bicarbonate and water and dried, and then the solvent was distilled off. The residue was purified by column chromatography (eluent: ethyl acetate) to obtain powder. The powder was washed with ether and dried to obtain 950 mg of the desired compound (yield: 87.3%, colorless powder).

المصدر