تفاعل #62144

معادلة التفاعل

4-(2-Quinolin-2-yl-ethyl)-benzoic acid

acetonitrile

O,N-Dimethyl-hydroxylamine hydrogen chloride

sodium hydroxide

→

title compound

المردود 88.0%

N-Methoxy-N-methyl-4-(2-quinolin-2-yl-ethyl)-benzamide

المردود 88.0%

المذيبات

dioxane

triethylamine

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with chloroform, dried magnesium sulfate
2. 2
   ترشيحfiltered
3. 3
   تركيزconcentrated
4. 4
   غسيلBiotage MPLC chromatography eluting with 20-50% ethyl acetate

الإجراء التجريبي

To a solution of 4-(2-Quinolin-2-yl-ethyl)-benzoic acid (530 mg) in dioxane 5 ml/acetonitrile 5 ml was added triethylamine (0.60 ml) and O,N-Dimethyl-hydroxylamine hydrogen chloride (240 mg). After 72 h, the reaction mixture was poured into 1N sodium hydroxide solution and extracted with chloroform, dried magnesium sulfate, filtered and concentrated. Biotage MPLC chromatography eluting with 20-50% ethyl acetate provided the title compound (516 mg, 88%). MS: (M+H m/z=321.1).

المصدر