تفاعل #62093

معادلة التفاعل

Methyl 2-chloro-3-{4-[2-(4-hydroxyphenoxy)ethyl]phenyl}propanoate

triethylamine

Methanesulfonyl chloride

→

pure product

المردود 96.0%

Methyl 2-chloro-3-[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]propanoate

المردود 96.0%

المذيبات

dichlormethane

dichlormethane

ظروف التفاعل

المعالجة

1. 1
   أخرىto reach room temperature
2. 2
   غسيلthe mixture was washed (water, brine)
3. 3
   تجفيفdried (Na2SO4)
4. 4
   أخرىevaporated under reduced pressure

الإجراء التجريبي

Methyl 2-chloro-3-{4-[2-(4-hydroxyphenoxy)ethyl]phenyl}propanoate (334 mg, 1.0 mmol) and triethylamine (303 mg, 3.0 mmol) was dissolved in 20 ml dichlormethane and cooled to −20° C. under nitrogen atmosphere. Methanesulfonyl chloride (114 mg, 1.0 mmol) was added dropwise. The mixture was allowed to reach room temperature. After 2 hours dichlormethane was added, the mixture was washed (water, brine), dried (Na2SO4) and evaporated under reduced pressure to yield 394 mg pure product (yield 96%).

المصدر