تفاعل #62031

معادلة التفاعل

potassium acetate

isoamyl nitrite

ester

methyl 2-amino-3-methylbenzoate

acetic anhydride

chloroform

→

methyl 1H-indazole-7-carboxylate hydrochloride

المردود 68.0%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwhile maintaining the temperature below 40° C
2. 2
   workup.ADDITIONwas added
3. 3
   درجة الحرارةThe reaction mixture was heated
4. 4
   درجة الحرارةat reflux for 24 h
5. 5
   غسيلThe reaction mixture was washed with a saturated, aqueous solution of sodium bicarbonate
6. 6
   تجفيفdried over sodium sulfate
7. 7
   تركيزconcentrated
8. 8
   workup.ADDITIONMethanol (100 mL) and 6 N hydrochloric acid (100 mL) were added to the residue
9. 9
   درجة الحرارةthe mixture was maintained for 18 h at rt
10. 10
    أخرىThe volatiles were removed under reduced pressure
11. 11
    أخرىthe residue was triturated with ethyl acetate (100 mL)
12. 12
    أخرىThe product was isolated by filteration
13. 13
    غسيلwashed with ethyl acetate (20 mL)
14. 14
    أخرىdried

الإجراء التجريبي

To a solution of the ester (17.5 g, 106 mmol) in chloroform (300 mL) was added acetic anhydride (22.6 mL, 239 mmol, 2.3 eq) while maintaining the temperature below 40° C. The reaction mixture was maintained at room temperature for 1 h when potassium acetate (3.00 g, 30.6 mmol, 0.3 eq) and isoamyl nitrite (30.6 mL, 228 mmol, 2.2 eqiv) was added. The reaction mixture was heated at reflux for 24 h and was allowed to cool to room temperature. The reaction mixture was washed with a saturated, aqueous solution of sodium bicarbonate, dried over sodium sulfate, and concentrated. Methanol (100 mL) and 6 N hydrochloric acid (100 mL) were added to the residue and the mixture was maintained for 18 h at rt. The volatiles were removed under reduced pressure and the residue was triturated with ethyl acetate (100 mL). The product was isolated by filteration, washed with ethyl acetate (20 mL), and dried to provide 15.3 g (68%) of methyl 1H-indazole-7-carboxylate hydrochloride. 1H NMR (500 MHz, DMSO-d6) δ 13.3 (bs, 1H), 8.26 (d, 1H), 8.12 (d, 1H), 8.25 (dd, 1H), 7.27 (t, 1H), 3.97 (s, 3H); MS (APCI) m/z 177 (M++1).

المصدر