تفاعل #619474

معادلة التفاعل

reactin

4-Chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

HCl

2-(2-Fluoropropoxy)pyridin-3-amine

→

Methyl-4-(2-(2-fluoropropoxy)pyridin-3-ylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate

المذيبات

dioxane

dioxane

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction was concentrated in vacuo

الإجراء التجريبي

2-(2-Fluoropropoxy)pyridin-3-amine (153 mg) was dissolved in dioxane (30 ml), 4-Chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester (174.54 mg) and HCl in dioxane (4M; 25 μl) was added. The reactin was stirred at 60° C. for three days. The reaction was concentrated in vacuo.

المصدر