تفاعل #619152

معادلة التفاعل

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-3-carboxylic acid benzyl ester

→

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-3-carboxylic acid

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   أخرىto degas the mixture
2. 2
   أخرى(24 h)
3. 3
   ترشيحAfter filtering
4. 4
   تركيزconcentration
5. 5
   أخرىthe pure acid was obtained by trituration

الإجراء التجريبي

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-3-carboxylic acid benzyl ester (30 mg, 0.057 mmol) was combined with palladium on carbon (20 mg) in MeOH. Vacuum was applied to degas the mixture. The reaction was subjected to hydrogen and vigorous stirring until no ester could be detected (24 h). After filtering and concentration, the pure acid was obtained by trituration.

المصدر