تفاعل #619150

معادلة التفاعل

{[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-amino}-acetic acid tert-butyl ester

Hydrogen chloride

→

desired compound

المردود 76.0%

{[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-amino}-acetic acid

المردود 76.0%

المذيبات

methylene chloride

diethyl ether

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated
2. 2
   workup.DISSOLUTIONThe resulting residue was dissolved in a minimum amount of methylene chloride
3. 3
   أخرىprecipitated with diethyl ether
4. 4
   أخرىdecanted

الإجراء التجريبي

{[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-amino}-acetic acid tert-butyl ester (14 mg, 0.03 mmol) was dissolved in methylene chloride. Hydrogen chloride (100 μL, 4N in dioxane) was added and the reaction was stirred at ambient temperature until no ester could be detected. The reaction was diluted with diethyl ether and concentrated. The resulting residue was dissolved in a minimum amount of methylene chloride, precipitated with diethyl ether and decanted. This was repeated to afford 9 mg (69%) of the desired compound. HPLC-MS: m/z 395 (M+1).

المصدر