تفاعل #619147

معادلة التفاعل

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-2(R)-carboxylic acid benzyl ester

→

pure acid

المردود 84.8%

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-yl-methyl]-pyrrolidine-2(R)-carboxylic acid

المردود 84.8%

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   أخرىto degas the mixture
2. 2
   أخرى(36 h)
3. 3
   ترشيحAfter filtering
4. 4
   تركيزconcentration

الإجراء التجريبي

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-2(R)-carboxylic acid benzyl ester (50 mg, 0.095 mmol) was combined with palladium on carbon (25 mg) in MeOH. Vacuum was applied to degas the mixture. The reaction was subjected to hydrogen and vigorous stirring until no ester could be detected (36 h). After filtering and concentration, 35 mg (84%) pure acid was obtained by trituration.

المصدر