تفاعل #619117

معادلة التفاعل

3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-acrylic acid ethyl ester

→

3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-propionic acid ethyl ester

المردود 47.7%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe content was degassed
2. 2
   ترشيحThe mixture was filtered through celite
3. 3
   تركيزthe filtrate was concentrated
4. 4
   أخرىThe residue was further purified by flash chromatography (silica, CH2Cl2-EtOAc 4:1

الإجراء التجريبي

To a solution of 3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-acrylic acid ethyl ester (Example 257) (75 mg, 0.18 mmol) in methanol was added Pd/C (150 mg). The content was degassed and was placed under hydrogen atmosphere for 12 h. The mixture was filtered through celite, and the filtrate was concentrated. The residue was further purified by flash chromatography (silica, CH2Cl2-EtOAc 4:1 to give 3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-propionic acid ethyl ester (35 mg) in 47% yield.

المصدر